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Phytochemistry and biological activity of Onosma rascheyana extracts (Boiss.)

Yıl 2022, Cilt: 2 Sayı: 1, 128 - 135, 15.06.2022

Öz

In recent years, it has been determined that Onosma species exhibit interesting biological/pharmacological activities. The aim of this study was to analyze the chemical composition, antioxidant and enzyme inhibitory activities of the methanol (MeOH), water and ethyl acetate extracts obtained from the aerials parts of Onosma rascheyana (Boiss.). The chemical compositions of the extracts were determined using spectrophotometric and chromatographic methods. Biological activities of the extracts were determined using antioxidant and enzyme inhibitory test systems. The MeOH extract was found to be rich in both phenolics and flavonoids (31.55 mg GAEs/g and 15.20 mg REs/g, respectively). The MeOH extract also contained higher amounts of 4-hydroxybenzoic and p-coumaric acids compared to other phytochemicals. The MeOH extract exhibited remarkable activity in all antioxidant test systems. However, 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonate) radical cation (ABTS) scavenging assay resulted in superiority of water extract (88.90 mg TEs/g). The relative antioxidant capacity indices (RACI) of the extracts and the correlations between these values and antioxidant activities confirmed the high activity of the MeOH extract. In the α-amylase, α-glucosidase, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity tests, the ethyl acetate extract showed high activity, while the tyrosinase inhibitory activity assay resulted in the superiority of the MeOH extract (59.72 mg KAEs/g). It was concluded that the extracts of O. rascheyana could be used as alternative agents in the food, cosmetic and medical industries due to their antioxidant and enzyme inhibitory activities.

Destekleyen Kurum

Scientific Research Council of Afyonkarahisar Health Sciences University

Proje Numarası

21.KARIYER.002

Kaynakça

  • Abesundara, K.J., Matsui, T., Matsumoto, K., 2004. α-Glucosidase inhibitory activity of some Sri Lanka plant extracts, one of which, Cassia auriculata, exerts a strong antihyperglycemic effect in rats comparable to the therapeutic drug acarbose. Journal of Agricultural and Food Chemistry, 52, 2541-2545.
  • Apak, R., Güçlü, K., Özyürek, M., Esin Karademir, S., Erçaǧ, E., 2006. The cupric ion reducing antioxidant capacity and polyphenolic content of some herbal teas. International Journal of Food Sciences and Nutrition, 57, 292-304.
  • Asanuma, M., Miyazaki, I., Ogawa, N., 2003. Dopamine-or L-DOPA-induced neurotoxicity: the role of dopamine quinone formation and tyrosinase in a model of Parkinson’s disease. Neurotoxicity Research, 5, 165-176.
  • Babaei, M., Zamfir, G.M.B., Chen, X., Christensen, H.B., Kristensen, M., Nielsen, J., Borodina, I., 2020. Metabolic Engineering of Saccharomyces cerevisiae for Rosmarinic Acid Production. ACS Synthetic Biology, 9, 1978-1988.
  • Cittan, M., Çelik, A., 2018. Development and validation of an analytical methodology based on Liquid Chromatography–Electrospray Tandem Mass Spectrometry for the simultaneous determination of phenolic compounds in olive leaf extract. Journal of Chromatographic Science, 56, 336-343.
  • El-Sayed, S.T., Al-Azzouny, R.A., Ali, O.S., 2019. Purification and functional characterization of a novel tyrosinase (diphenolase) inhibitory peptides prepared from Solunum tuberosum peels protein via enzymatic hydrolysis. Biocatalysis and Agricultural Biotechnology, 17, 331-338.
  • Fan, M., Zhang, G., Hu, X., Xu, X., Gong, D., 2017. Quercetin as a tyrosinase inhibitor: Inhibitory activity, conformational change and mechanism. Food Research International, 100, 226-233.
  • Funke, I., Melzig, M.F., 2006. Traditionally used plants in diabetes therapy: phytotherapeutics as inhibitors of alpha-amylase activity. Revista Brasileira de Farmacognosia, 16, 1-5.
  • Gheibi, N., Taherkhani, N., Ahmadi, A., Haghbeen, K., Ilghari, D., 2015. Characterization of inhibitory effects of the potential therapeutic inhibitors, benzoic acid and pyridine derivatives, on the monophenolase and diphenolase activities of tyrosinase. Iranian Journal of Basic Medical Sciences, 18, 122-129.
  • Kamkaen, N., Mulsri, N., Treesak, C., 2007. Screening of some tropical vegetables for anti-tyrosinase activity. Thai Pharmaceutical and Health Science Journal, 2, 15-19.
  • Kim, D.K., Jeon, H., Cha, D.S., 2014. 4-Hydroxybenzoic acid-mediated lifespan extension in Caenorhabditis elegans. Journal of Functional Foods, 7, 630-640.
  • Kim, Y.M., Jeong, Y.K., Wang, M.H., Lee, W.Y., Rhee, H.I., 2005. Inhibitory effect of pine extract on α-glucosidase activity and postprandial hyperglycemia. Nutrition, 21, 756-761.
  • Kirkan, B., Sarikurkcu, C., Ozer, M.S., Cengiz, M., Atilgan, N., Ceylan, O., Tepe, B., 2018. Phenolic profile, antioxidant and enzyme inhibitory potential of Onosma tauricum var. tauricum. Industrial Crops and Products, 125, 549-555.
  • Kocak, M.S., Sarikurkcu, C., Cengiz, M., Kocak, S., Uren, M.C., Tepe, B., 2016. Salvia cadmica: Phenolic composition and biological activity. Industrial Crops and Products, 85, 204-212.
  • Kubo, I., Kinst-Hori, I., Chaudhuri, S.K., Kubo, Y., Sánchez, Y., Ogura, T., 2000. Flavonols from Heterotheca inuloides: tyrosinase inhibitory activity and structural criteria. Bioorganic & Medicinal Chemistry, 8, 1749-1755.
  • Loizzo, M., Tundis, R., Menichini, F., 2012. Natural and synthetic tyrosinase inhibitors as antibrowning agents: an update. Comprehensive Reviews in Food Science and Food Safety, 11, 378-398.
  • Madsen, H.L., Bertelsen, G., 1995. Spices as antioxidants. Trends in Food Science & Technology, 6, 271-277.
  • Ozer, M.S., Kirkan, B., Sarikurkcu, C., Cengiz, M., Ceylan, O., Atilgan, N., Tepe, B., 2018. Onosma heterophyllum: Phenolic composition, enzyme inhibitory and antioxidant activities. Industrial Crops and Products, 111, 179-184.
  • Park, S.U., Uddin, M.R., Xu, H., Kim, Y.K., Lee, S.Y., 2008. Biotechnological applications for rosmarinic acid production in plant. African Journal of Biotechnology, 7, 4959-4965.
  • Saghaie, L., Pourfarzam, M., Fassihi, A., Sartippour, B., 2013. Synthesis and tyrosinase inhibitory properties of some novel derivatives of kojic acid. Research in Pharmaceutical Sciences, 8, 233-242.
  • Saravanakumar, K., Sarikurkcu, C., Sarikurkcu, R.T., Wang, M.H., 2019. A comparative study on the phenolic composition, antioxidant and enzyme inhibition activities of two endemic Onosma species. Industrial Crops and Products, 142, 111878.
  • Sarikurkcu, C., Kirkan, B., Ozer, M.S., Ceylan, O., Atilgan, N., Cengiz, M., Tepe, B., 2018. Chemical characterization and biological activity of Onosma gigantea extracts. Industrial Crops and Products, 115, 323-329.
  • Sarikurkcu, C., Kocak, M.S., Tepe, B., Uren, M.C., 2015. An alternative antioxidative and enzyme inhibitory agent from Turkey: Robinia pseudoacacia L. Industrial Crops and Products, 78, 110-115.
  • Sarikurkcu, C., Sahinler, S.S., Ceylan, O., Tepe, B., 2020a. Onosma ambigens: Phytochemical composition, antioxidant and enzyme inhibitory activity. Industrial Crops and Products, 154, 112651.
  • Sarikurkcu, C., Sahinler, S.S., Ceylan, O., Tepe, B., 2020b. Onosma pulchra: Phytochemical composition, antioxidant, skin-whitening and anti-diabetic activity. Industrial Crops and Products, 154, 112632.
  • Sarikurkcu, C., Sahinler, S.S., Husunet, M.T., Istifli, E.S., Tepe, B., 2020c. Two endemic Onosma species (O. sieheana and O. stenoloba): A comparative study including docking data on biological activity and phenolic composition. Industrial Crops and Products, 154, 112656.
  • Sarikurkcu, C., Sahinler, S.S., Tepe, B., 2020d. Onosma aucheriana, O. frutescens, and O. sericea: Phytochemical profiling and biological activity. Industrial Crops and Products, 154, 112633.
  • Sasaki, Y.F., Kawaguchi, S., Kamaya, A., Ohshita, M., Kabasawa, K., Iwama, K., Taniguchi, K., Tsuda, S., 2002. The comet assay with 8 mouse organs: results with 39 currently used food additives. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 519, 103-119.
  • Schwarz, K., Bertelsen, G., Nissen, L.R., Gardner, P.T., Heinonen, M.I., Hopia, A., Huynh-Ba, T., Lambelet, P., McPhail, D., Skibsted, L.H., 2001. Investigation of plant extracts for the protection of processed foods against lipid oxidation. Comparison of antioxidant assays based on radical scavenging, lipid oxidation and analysis of the principal antioxidant compounds. European Food Research and Technology, 212, 319-328.
  • Tanabe, H., Yoshida, M., Tomita, N., 2002. Comparison of the antioxidant activities of 22 commonly used culinary herbs and spices on the lipid oxidation of pork meat. Animal Science Journal, 73, 389-393.
  • Tepe, B., Sarikurkcu, C., Berk, S., Alim, A., Akpulat, H.A., 2011. Chemical composition, radical scavenging and antimicrobial activity of the essential oils of Thymus boveii and Thymus hyemalis. Records of Natural Products, 5, 208-220.
  • Tlili, N., Sarikurkcu, R.T., Ceylan, O., Sarikurkcu, C., 2021. Onosma polyantha vs. Onosma mollis: Analysis of Phenolic Compounds Using Liquid Chromatography–Electrospray Ionization Tandem Mass Spectrometry (LC-ESI-MS/MS) and Assessment of the Antioxidant Activity. Analytical Letters, 54, 1389-1400.
  • Ying, W., Calas-Blanchard, C., Cortina-Puig, M., Liu, B.H., Marty, J.L., 2009. An Electrochemical Method for Sensitive Determination of Antioxidant Capacity. Electroanalysis, 21, 1395-1400.
  • Zengin, G., Sarikurkcu, C., Gunes, E., Uysal, A., Ceylan, R., Uysal, S., Gungor, H., Aktumsek, A., 2015. Two Ganoderma species: Profiling of phenolic compounds by HPLC-DAD, antioxidant, antimicrobial and inhibitory activities on key enzymes linked to diabetes mellitus, Alzheimer's disease and skin disorders. Food and Function, 6, 2794-2802.
Yıl 2022, Cilt: 2 Sayı: 1, 128 - 135, 15.06.2022

Öz

Proje Numarası

21.KARIYER.002

Kaynakça

  • Abesundara, K.J., Matsui, T., Matsumoto, K., 2004. α-Glucosidase inhibitory activity of some Sri Lanka plant extracts, one of which, Cassia auriculata, exerts a strong antihyperglycemic effect in rats comparable to the therapeutic drug acarbose. Journal of Agricultural and Food Chemistry, 52, 2541-2545.
  • Apak, R., Güçlü, K., Özyürek, M., Esin Karademir, S., Erçaǧ, E., 2006. The cupric ion reducing antioxidant capacity and polyphenolic content of some herbal teas. International Journal of Food Sciences and Nutrition, 57, 292-304.
  • Asanuma, M., Miyazaki, I., Ogawa, N., 2003. Dopamine-or L-DOPA-induced neurotoxicity: the role of dopamine quinone formation and tyrosinase in a model of Parkinson’s disease. Neurotoxicity Research, 5, 165-176.
  • Babaei, M., Zamfir, G.M.B., Chen, X., Christensen, H.B., Kristensen, M., Nielsen, J., Borodina, I., 2020. Metabolic Engineering of Saccharomyces cerevisiae for Rosmarinic Acid Production. ACS Synthetic Biology, 9, 1978-1988.
  • Cittan, M., Çelik, A., 2018. Development and validation of an analytical methodology based on Liquid Chromatography–Electrospray Tandem Mass Spectrometry for the simultaneous determination of phenolic compounds in olive leaf extract. Journal of Chromatographic Science, 56, 336-343.
  • El-Sayed, S.T., Al-Azzouny, R.A., Ali, O.S., 2019. Purification and functional characterization of a novel tyrosinase (diphenolase) inhibitory peptides prepared from Solunum tuberosum peels protein via enzymatic hydrolysis. Biocatalysis and Agricultural Biotechnology, 17, 331-338.
  • Fan, M., Zhang, G., Hu, X., Xu, X., Gong, D., 2017. Quercetin as a tyrosinase inhibitor: Inhibitory activity, conformational change and mechanism. Food Research International, 100, 226-233.
  • Funke, I., Melzig, M.F., 2006. Traditionally used plants in diabetes therapy: phytotherapeutics as inhibitors of alpha-amylase activity. Revista Brasileira de Farmacognosia, 16, 1-5.
  • Gheibi, N., Taherkhani, N., Ahmadi, A., Haghbeen, K., Ilghari, D., 2015. Characterization of inhibitory effects of the potential therapeutic inhibitors, benzoic acid and pyridine derivatives, on the monophenolase and diphenolase activities of tyrosinase. Iranian Journal of Basic Medical Sciences, 18, 122-129.
  • Kamkaen, N., Mulsri, N., Treesak, C., 2007. Screening of some tropical vegetables for anti-tyrosinase activity. Thai Pharmaceutical and Health Science Journal, 2, 15-19.
  • Kim, D.K., Jeon, H., Cha, D.S., 2014. 4-Hydroxybenzoic acid-mediated lifespan extension in Caenorhabditis elegans. Journal of Functional Foods, 7, 630-640.
  • Kim, Y.M., Jeong, Y.K., Wang, M.H., Lee, W.Y., Rhee, H.I., 2005. Inhibitory effect of pine extract on α-glucosidase activity and postprandial hyperglycemia. Nutrition, 21, 756-761.
  • Kirkan, B., Sarikurkcu, C., Ozer, M.S., Cengiz, M., Atilgan, N., Ceylan, O., Tepe, B., 2018. Phenolic profile, antioxidant and enzyme inhibitory potential of Onosma tauricum var. tauricum. Industrial Crops and Products, 125, 549-555.
  • Kocak, M.S., Sarikurkcu, C., Cengiz, M., Kocak, S., Uren, M.C., Tepe, B., 2016. Salvia cadmica: Phenolic composition and biological activity. Industrial Crops and Products, 85, 204-212.
  • Kubo, I., Kinst-Hori, I., Chaudhuri, S.K., Kubo, Y., Sánchez, Y., Ogura, T., 2000. Flavonols from Heterotheca inuloides: tyrosinase inhibitory activity and structural criteria. Bioorganic & Medicinal Chemistry, 8, 1749-1755.
  • Loizzo, M., Tundis, R., Menichini, F., 2012. Natural and synthetic tyrosinase inhibitors as antibrowning agents: an update. Comprehensive Reviews in Food Science and Food Safety, 11, 378-398.
  • Madsen, H.L., Bertelsen, G., 1995. Spices as antioxidants. Trends in Food Science & Technology, 6, 271-277.
  • Ozer, M.S., Kirkan, B., Sarikurkcu, C., Cengiz, M., Ceylan, O., Atilgan, N., Tepe, B., 2018. Onosma heterophyllum: Phenolic composition, enzyme inhibitory and antioxidant activities. Industrial Crops and Products, 111, 179-184.
  • Park, S.U., Uddin, M.R., Xu, H., Kim, Y.K., Lee, S.Y., 2008. Biotechnological applications for rosmarinic acid production in plant. African Journal of Biotechnology, 7, 4959-4965.
  • Saghaie, L., Pourfarzam, M., Fassihi, A., Sartippour, B., 2013. Synthesis and tyrosinase inhibitory properties of some novel derivatives of kojic acid. Research in Pharmaceutical Sciences, 8, 233-242.
  • Saravanakumar, K., Sarikurkcu, C., Sarikurkcu, R.T., Wang, M.H., 2019. A comparative study on the phenolic composition, antioxidant and enzyme inhibition activities of two endemic Onosma species. Industrial Crops and Products, 142, 111878.
  • Sarikurkcu, C., Kirkan, B., Ozer, M.S., Ceylan, O., Atilgan, N., Cengiz, M., Tepe, B., 2018. Chemical characterization and biological activity of Onosma gigantea extracts. Industrial Crops and Products, 115, 323-329.
  • Sarikurkcu, C., Kocak, M.S., Tepe, B., Uren, M.C., 2015. An alternative antioxidative and enzyme inhibitory agent from Turkey: Robinia pseudoacacia L. Industrial Crops and Products, 78, 110-115.
  • Sarikurkcu, C., Sahinler, S.S., Ceylan, O., Tepe, B., 2020a. Onosma ambigens: Phytochemical composition, antioxidant and enzyme inhibitory activity. Industrial Crops and Products, 154, 112651.
  • Sarikurkcu, C., Sahinler, S.S., Ceylan, O., Tepe, B., 2020b. Onosma pulchra: Phytochemical composition, antioxidant, skin-whitening and anti-diabetic activity. Industrial Crops and Products, 154, 112632.
  • Sarikurkcu, C., Sahinler, S.S., Husunet, M.T., Istifli, E.S., Tepe, B., 2020c. Two endemic Onosma species (O. sieheana and O. stenoloba): A comparative study including docking data on biological activity and phenolic composition. Industrial Crops and Products, 154, 112656.
  • Sarikurkcu, C., Sahinler, S.S., Tepe, B., 2020d. Onosma aucheriana, O. frutescens, and O. sericea: Phytochemical profiling and biological activity. Industrial Crops and Products, 154, 112633.
  • Sasaki, Y.F., Kawaguchi, S., Kamaya, A., Ohshita, M., Kabasawa, K., Iwama, K., Taniguchi, K., Tsuda, S., 2002. The comet assay with 8 mouse organs: results with 39 currently used food additives. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 519, 103-119.
  • Schwarz, K., Bertelsen, G., Nissen, L.R., Gardner, P.T., Heinonen, M.I., Hopia, A., Huynh-Ba, T., Lambelet, P., McPhail, D., Skibsted, L.H., 2001. Investigation of plant extracts for the protection of processed foods against lipid oxidation. Comparison of antioxidant assays based on radical scavenging, lipid oxidation and analysis of the principal antioxidant compounds. European Food Research and Technology, 212, 319-328.
  • Tanabe, H., Yoshida, M., Tomita, N., 2002. Comparison of the antioxidant activities of 22 commonly used culinary herbs and spices on the lipid oxidation of pork meat. Animal Science Journal, 73, 389-393.
  • Tepe, B., Sarikurkcu, C., Berk, S., Alim, A., Akpulat, H.A., 2011. Chemical composition, radical scavenging and antimicrobial activity of the essential oils of Thymus boveii and Thymus hyemalis. Records of Natural Products, 5, 208-220.
  • Tlili, N., Sarikurkcu, R.T., Ceylan, O., Sarikurkcu, C., 2021. Onosma polyantha vs. Onosma mollis: Analysis of Phenolic Compounds Using Liquid Chromatography–Electrospray Ionization Tandem Mass Spectrometry (LC-ESI-MS/MS) and Assessment of the Antioxidant Activity. Analytical Letters, 54, 1389-1400.
  • Ying, W., Calas-Blanchard, C., Cortina-Puig, M., Liu, B.H., Marty, J.L., 2009. An Electrochemical Method for Sensitive Determination of Antioxidant Capacity. Electroanalysis, 21, 1395-1400.
  • Zengin, G., Sarikurkcu, C., Gunes, E., Uysal, A., Ceylan, R., Uysal, S., Gungor, H., Aktumsek, A., 2015. Two Ganoderma species: Profiling of phenolic compounds by HPLC-DAD, antioxidant, antimicrobial and inhibitory activities on key enzymes linked to diabetes mellitus, Alzheimer's disease and skin disorders. Food and Function, 6, 2794-2802.
Toplam 34 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Eczacılık ve İlaç Bilimleri
Bölüm Research Articles
Yazarlar

Cengiz Sarıkürkcü 0000-0001-5094-2520

Ersin Demir 0000-0001-9180-0609

Mehmet Sabih Ozer 0000-0002-3139-2938

Rıza Binzet Bu kişi benim 0000-0003-0336-8305

Proje Numarası 21.KARIYER.002
Yayımlanma Tarihi 15 Haziran 2022
Gönderilme Tarihi 29 Aralık 2021
Yayımlandığı Sayı Yıl 2022 Cilt: 2 Sayı: 1

Kaynak Göster

APA Sarıkürkcü, C., Demir, E., Ozer, M. S., Binzet, R. (2022). Phytochemistry and biological activity of Onosma rascheyana extracts (Boiss.). International Journal of Plant Based Pharmaceuticals, 2(1), 128-135.
AMA Sarıkürkcü C, Demir E, Ozer MS, Binzet R. Phytochemistry and biological activity of Onosma rascheyana extracts (Boiss.). Int. J. Plant Bas. Pharm. Haziran 2022;2(1):128-135.
Chicago Sarıkürkcü, Cengiz, Ersin Demir, Mehmet Sabih Ozer, ve Rıza Binzet. “Phytochemistry and Biological Activity of Onosma Rascheyana Extracts (Boiss.)”. International Journal of Plant Based Pharmaceuticals 2, sy. 1 (Haziran 2022): 128-35.
EndNote Sarıkürkcü C, Demir E, Ozer MS, Binzet R (01 Haziran 2022) Phytochemistry and biological activity of Onosma rascheyana extracts (Boiss.). International Journal of Plant Based Pharmaceuticals 2 1 128–135.
IEEE C. Sarıkürkcü, E. Demir, M. S. Ozer, ve R. Binzet, “Phytochemistry and biological activity of Onosma rascheyana extracts (Boiss.)”, Int. J. Plant Bas. Pharm., c. 2, sy. 1, ss. 128–135, 2022.
ISNAD Sarıkürkcü, Cengiz vd. “Phytochemistry and Biological Activity of Onosma Rascheyana Extracts (Boiss.)”. International Journal of Plant Based Pharmaceuticals 2/1 (Haziran 2022), 128-135.
JAMA Sarıkürkcü C, Demir E, Ozer MS, Binzet R. Phytochemistry and biological activity of Onosma rascheyana extracts (Boiss.). Int. J. Plant Bas. Pharm. 2022;2:128–135.
MLA Sarıkürkcü, Cengiz vd. “Phytochemistry and Biological Activity of Onosma Rascheyana Extracts (Boiss.)”. International Journal of Plant Based Pharmaceuticals, c. 2, sy. 1, 2022, ss. 128-35.
Vancouver Sarıkürkcü C, Demir E, Ozer MS, Binzet R. Phytochemistry and biological activity of Onosma rascheyana extracts (Boiss.). Int. J. Plant Bas. Pharm. 2022;2(1):128-35.